A strong staring line up with seven first teamers as Wayne Brown; Mayor; Carter; Russell; Parry; Hume and Chris Brown were in the first eleven.
The first goal was scored on 17 minutes by Parry with Hume doubling the lead three minutes later.
PNE made it 3-0 on 22 minutes via Chris Brown and scored his second on 31 minutes from the penalty spot.
Wrexham pulled two goals back in the second half.
With Burnley reserves losing 4-3 to bottom placed Bury, Preston are second and three points behind the Clarets with two games in hand as the Lilywhites leapfrog over Wrexham