Wolves look a good bet for the play-offs and had man-of-the-match George Ndah, who scored the opening goal, and Kenny Miller, who scored the other goal, to thank.
Preston had a great chance early in the game in just the fourth minute when a good move involving Lee Cartwright and Graham Alexander led to a right-foot cross falling to George Koumantarakis, who had a free header from close range which he put just wide of the left-hand post.
Ndah had a shot which went just wide of the right-hand post after a run down the right-hand side after a quarter of an hour.
In the 24th minute Koumantarakis passed the ball to Paul McKenna and he had a right-foot shot which went just wide of the right-hand post.
Brian O'Neil had a header after 25 minutes from 12 yards out which went just over the bar following a Alexander right-foot right-wing corner.
Wolves had Colin Cameron limp off injured three minutes from the break and they brought on substitute Keith Andrews.
The fourth official signalled two minutes extra but the teams went in goalless at half time.
Wolves made it 1-0 in the 2nd minute when a brilliant run by Ndah down the left led to him beating three defenders and he ran 40 yards before firing a 15-yard left-foot shot into the bottom left corner of the net.
Paul Ince was then booked after 73 minutes for a foul on McKenna.
Wolves made it 2-0 after 83 minutes when Adam Proudlock hit a right-foot right-wing cross to Miller, who scored left-footed from five yards into the bottom left-hand corner.
Richard Cresswell hit the right-hand post from ten yards in the last minute.